Name: REPLIGEN XCell ATF Series
Brand: REPLIGEN
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XCell

ATF System with C410:V4B Controller User Guide

1.3 Select Profibus Device Type

Select the correct Profibus Type (Generated by the GSD file). In this case a Siemens CM 1242-5

card is shown.

1.4 Address Setting

Verify that the “Enabled” checkbox is checked and the “Address” field matches the Address set

on the Admin page on the HMI.

1.5 Confirm and Select “OK” button

Default Chapter3
- Table of Contents3
1 Description of the Xcell™ ATF (Alternating Tangential Flow) System and Process5
- Xcell TM ATF System Pump Cycle7
- Xcell™ ATF System Control Scope and Objectives9
2 Utility Requirements9
3 Dimensions and Weight10
4 Xcell™ ATF Pump Housing Assemblies11
See Appendix 7 for List of Spares and Accessories16
5 Xcell TM C410V4B Controller Layout21
- General Layout21
- Filtration Assembly (Stainless Steel)22
- Pneumatics Box (P-Box) Components22
- Electrical Box (E-Box)22
- Power Box (Power Separation) Components24
- Primary Pneumatic Services24
- Primary Electric Services25
- Signal25
6 C410V4B Controller Process and Control26
- Control Overview26
- Control Functional Algorithms28
- Interface and Screens29
- Startup54
- Examples56
7 Xcell™ ATF Hollow Fiber Module and Diaphragm Replacement58
- Separating the Filtration Assembly from the Bioreactor58
- HFM Removal58
- HFM Insertion59
- Screen Module Replacement60
- Diaphragm Replacement60
- Assembly61
- Use61
8 Sterilization62
- Preparation of Filtration Assembly for Autoclaving62
- Autoclave Cycle63
- Sterilization of Filtrate / Harvest Line64
9 Connection to Bioreactor (ATF-To-Bioreactor)65
- Hard Connection65
10 Maintenance66
- Diaphragm66
- Pump Air Inlet Filter66
- O" Rings, Gaskets and Quick Connects66
Appendix 1: Cycle Time Vs. Flow Rate67
Appendix 2: Access Levels to the C410V4B Controller68
Appendix 3: Controller Lists: Alarm, Warning, Inputs & Outputs75
Appendix 4: Profinet Communication77
Appendix 5: Profibus Communication79
Appendix 6: Delta V Example Configuration100
Appendix 7: OPC Communication107
Appendix 8: Audit Trail (if Equipped)117
Appendix 9: EU Declaration of Conformity120
Appendix 10: UL Listing123
Appendix 11: Spares List124

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REPLIGEN XCell ATF Series Specifications

General

Brand	REPLIGEN
Model	XCell ATF Series
Category	Laboratory Equipment
Language	English

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REPLIGEN XCell ATF Series User Manual

Table of Contents

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REPLIGEN XCell ATF Series Specifications

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