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KrosFlo SYITF-2000
REPLIGEN KrosFlo SYITF-2000 User Manual
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1
IF
.U
G.
IM
_R1
KrosFlo®
System
s
User Gu
ide
For use wit
h:
•
KrosFlo® KT
F Tangen
tial F
low Filt
ration (TFF) S
ystem
•
KrosFlo® KP
S Perfu
sion
(
KPS) Syst
em
•
KrosFlo® TFD
F® Ta
ngentia
l Flow Dept
h Filt
ration (TFD
F) System
2
Table of Contents
Table of Contents
3
Introduction
7
Safety Precautions
7
Signal Words
7
Table 1. Signal Words, Definitions, and Colors
7
Safety Symbol Icons
8
Table 2. Safety Symbol Icons
8
Safety Guidelines
9
Intended User Guide Audience
9
Intended Use of the System
10
Warnings for Moving, Installing, and Storing the System
10
Warning for System Preparations
11
Warnings for System Operation
11
Warnings for System Maintenance
14
System Specifications
15
Table 3. Krosflo® System Feature/Component Specifications
15
Table 4. Krosflo® System Electrical Specifications
16
Table 5. Krosflo® System Environmental Specifications
16
Figure 1. Sample Machine Designation Label
16
System Dimensions
17
Rohs and WEEE Compliance
17
Figure 2. Krosflo® System Dimensions
17
System Overview
18
Main System
18
Figure 3. Krosflo® System Overview
18
Cassette Holder Cart (Optional)
19
Auxiliary Cart (Optional)
19
Figure 4. Optional Cassette Holder Cart
19
Figure 5. Optional Auxiliary Cart
19
Unpacking the System
20
Performing Mechanical Installation
21
Main System Assembly
21
Figure 6. Pump Stand Assembly
22
Cassette Holder Assembly (Optional)
23
Cassettes Installation
23
Figure 7. Cassette Installation
23
Hydraulic Pump Preparation
24
Figure 8. Hydraulic Pump Components
24
Single-Use Flow-Path Assembly
26
Recirculation Pump Preparation and Connections
26
Figure 9. Typical Flow Path with Hollow Fiber and Cassette Filter Connections
26
Feed Tank/Reservoir Connections
30
Figure 10. Typical Feed Tank or Reservoir Connections
30
Installing Auxiliary Pump Tubing
32
Performing Electrical Installation
33
Sensor and Communication Cables
33
Pressure Sensors
33
Installing Ferrite Bead for Pressure Sensors
34
Installing Permeate Flow Sensors
35
Other Sensor and Communication Cables
35
Connecting the System Power Cables
36
Using the System HMI
36
Human Machine Interface (HMI) Overview
36
Getting Started
37
Loading and Running Recipes
38
Figure 11. Recipe Selection Screen
38
Home Screen
39
Figure 12. Sample Home Screen
39
Process Screen
40
Figure 13. Sample Process Screen
40
Alarms Screen
42
Figure 14. Sample Alarms Screen
42
Diagnostics Screen
43
Figure 15. Sample Diagnostics Screen
43
Operating the System
44
Executing Reports
44
System Emergency Stop and Responses
45
Stopping the System Using the E-Stop Button
45
Restarting the System after an Emergency Stop
45
System Power Loss and Responses
46
System Power Loss
46
Restarting the System after a Power Loss
46
Shutting down the System
46
Performing System Maintenance
47
Making the System Safe for Maintenance
47
Cleaning the System
47
Cleaning the Flow-Path
47
Flow-Path Disassembly and Storage
48
System Moving and Storage
48
Krosflo® System Spare Parts
49
Table 6. Krosflo® System Spare Parts
49
Troubleshooting the System
52
Table 7. Basic System Troubleshooting Steps
52
Index
53
4
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REPLIGEN KrosFlo SYITF-2000 Specifications
General
Brand
REPLIGEN
Model
KrosFlo SYITF-2000
Category
Laboratory Equipment
Language
English
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