IF.UG.IM_R1
14. Troubleshooting the System
If you encounter an issue with System operations, refer to the table below for basic troubleshooting
suggestions. Contact Repligen Customer Service (customerserviceUS@repligen.com / 1-508-845-
3030 (Option 1)) if issues persist.
Table 7. Basic System Troubleshooting Steps
Pump does not
run
No power at motor
Check if there is any error light or message on pump
controller, located inside the cabinet.
Check if there is any fuse is blown.
A qualified electrician to check motor power cables for
damages or loose connections.
Interlock is active
Find the active interlock and resolve the problem causing the
interlock to be activated.
Peristaltic (permeate/buffer/product)
pumps are in the wrong mode.
Ensure permeate/buffer/product pumps are in the correct
mode (remote).
Pump does not
deliver required
flow rate
Broken or worn-out components in pump
head, and/or there is some noise.
Replace pump head unit. Consult the pump operating
instructions in the pump user manual.
Tubing is bent or occluded.
Check HMI for abnormal pressure values, then check tubing
for any potential occlusion.
Increased
running noise
Pump or tubing cavitation
Slightly reorient or shake the tubing so that the air bubbles
can flow through
System does
not power up
The facility’s primary disconnect is in “off”
position.
A qualified electrician should check the power cables from
facility power source to the power outlet, then to the
System’s main disconnect.
System power plug is not plugged in.
Plug power plug into the power outlet.
System’s main disconnect is in “off” position.
Turn the main disconnect clockwise to “on” position.
System does
not run
Alarm or Interlock is active
Navigate to the Alarms screen, resolve the issues that caused
the alarm(s) or Interlock, then acknowledge the alarms and
press “Reset” button.
Emergency Stop button is active
Resolve the issue, then rotate and pull the E-stop, then press
“Reset” button.
User does not have the right access level
Ask a user with appropriate access level to complete the task.
value from
pressure sensor
Sensor cables are not connected
Connect the cables following their respective tag numbers.
Sensor is damaged Replace the sensor
on HMI seem
not right
Pressure sensor cables are plugged
incorrectly.
Connect the cables following their respective tag numbers.
Fluid leaks
Components on flow-path are damaged or
ruptured.
Stop the System, wait for the leaks to stop, drain the flow-
path, and replace it.
keyboard has
disappeared
User press “exit” on keyboard application.
Press the keyboard icon located in the bottom left corner of
the navigation pane.
modules are
not propagating
properly
User is not waiting 30 seconds after
selecting a filter type before selecting a filter
module on the Settings screen.
To avoid possible issues, it is important wait 30 seconds for
the selected filter module type to propagate before selecting
an individual filter module for use in a TFF process.