repligen.com IF.UG.028 R1
1. Introduction
KrosFlo® Systems from Repligen provide ready-to-use, flexible flow path solutions for commercial-
scale microfiltration and ultrafiltration process operations. The systems include one or two
magnetically driven centrifugal pump heads, custom ProConnex® Flow Paths, flow meters, peristaltic
pumps, Spectrum® Hollow Fiber Filters, KrosFlo® TFDF® Filters and optional connections for a weight
scale for additional process monitoring.
Other components of the system include the retentate flow meters, permeate flow meter, pressure
sensors, Repligen control panel controlled by an Allen-Bradley PLC, using an iFIX-based HMI program
to initiate actions, flexible tube flow path, and a Repligen stainless steel frame/cart that serve as the
system support structure.
2. Safety precautions
2.1 Signal words
The signal word and color distinguish the severity level of a hazard. Signal word definitions and
colors are listed in Table 1
.
Table 1. Signal words, definitions and colors
2.2 Safety symbol icons
The typical safety symbol icons - hazard, prohibition, and mandatory action - used on Repligen
systems are listed in Table 2
. The icons are pictograms that communicate hazards quickly and across
language barriers.
Description
Safety Alert Symbol (SAS) - used when a hazard to personnel is present. The SAS is
omitted when the hazard is related to property/equipment damage only.
A DANGER notification indicates an imminently hazardous situation which, if not
avoided, will result in death or serious injury.
A WARNING notification indicates a potentially hazardous situation which, if not
avoided, could result in death or serious injury.
A CAUTION notification indicates a potentially hazardous situation which, if not avoided,
may result in minor or moderate injury.
A CAUTION notification without the Safety Alert Symbol indicates a potentially
hazardous situation which, if not avoided, may result in property/equipment damage.
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