ActionStep
When the filling sequence is completed, let the system stand for 60 minutes.2
See Section Section8.5 UNICORN method for system CIP/Sanitization/Rinsing, on page 172
for an example of a UNICORN method for a two-pump, 10 mm inner diameter system.
After cleaning
•
After CIP/Sanitization, rinse all flow paths in the system with water or suitable liquid
until these are completely free from cleaning solution (when applicable, the system
conductivity monitors can be used as detectors).
•
The UNICORN method used for filling the system with 1 M sodium hydroxide can also
be used for rinsing. However, the CIP inlet valve has to be changed in the method
(to CIP 2 - water - in this example).
•
Do not leave sodium hydroxide or other cleaning solutions in the system.
•
If the system is to be stored after the CIP/Sanitization, the same UNICORN method,
again with a changed CIP inlet (CIP 3 - 20% ethanol - in this example) can be used
to fill the system with a suitable storage solution. Refer to Section 6.3 Storage, on
page 144.
ÄKTAprocess Operating Instructions 29-0252-49 AA 143
6 Maintenance
6.2 Cleaning
6.2.3 General procedure for CIP and sanitization
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