56
b4. Press the HFM with “O” ring firmly into the housing.
Assure the “O” ring is inserted smoothly and uniformly. Lubricate with WFI to facilitate this
process.
b5. Press until the HFM “O” ring groove is exposed at the other end, the Drain nozzle
end.
b6. Place 2
nd
“O” ring on the exposed end.
b7. Press the HFM back into the Filter Housing until both “O” rings seal against the
housing ID.
b8. Assemble the system.
1.3.2 I-Line HFM insertion:
c1. Stand the Filter Housing vertically, with harvest port up.
c2. Insert the HFM into the housing
c3. Insert one “O” ring into the groove formed between HFM and Filter Housing end-
ferrule wall.
c4. Place the reducer onto the end, forcing the “O” ring into the groove.
c5. Clamp the reducer to the housing, the compressed “O” ring is forced against the
HFM. A seal is formed between the Housing, Reducer and HFM
c6. On the other end of the Filter Housing, Place the second “O” ring into the formed
groove between HFM and Housing end-ferrule.
c7. Carefully place the Filter Housing onto the Diaphragm Pump, forcing the “O” ring
deeper into the groove.
c8. Clamp the Filter Housing to the Diaphragm Pump.
c9. Assemble the XCell™ ATF System.
7.4 Screen Module replacement
If the SM is being used, contact Repligen at Customer Service at Sales@Repligen.com for
replacement instructions.
7.5 Diaphragm replacement
Replacement or placement of a diaphragm within the Diaphragm Pump is part of the Diaphragm
Pump assembly process which differs slightly among the XCell™ ATF 4 System, XCell™ ATF 6 System,
XCell™ ATF 8 System and XCell™ ATF 10 System.
Diaphragm Replacement Procedure for the XCell™ ATF 4 System, XCell™ ATF 6 System and XCell™
ATF 8 System
d1. Place cleaned Diaphragm Pump hemispheres, diaphragm and pump clamp on a table top
d2. Place the PL pump hemisphere (hemisphere with a nozzle on the side) with the large
opening in the upward position.
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