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d3. Place diaphragm, pointing down into the PL pump hemisphere with the nipple of the
diaphragm orientated towards the ceiling. Assure the diaphragm gasket “O” ring is
positioned uniformly about the periphery of the pump “O” ring groove.
d4. Mate the PA-pump hemisphere, wide opening down, with the diaphragm in PL pump
hemisphere. Assure the diaphragm gasket “O” ring is positioned uniformly about the
periphery of the PA “O” ring groove.
d5. The two hemispheres, with diaphragm in between, should be equally spaced.
d6. Clamp the two hemispheres together.
d7. Secure the Diaphragm Pump to the stand.
Diaphragm Replacement Procedure for the XCell™ ATF 10 System
e1. The diaphragm within the Diaphragm Pump of the XCell™ ATF 10 System contains a short
right-angle bend on the diaphragm periphery which mates with a counterpart groove in
the PA pump hemisphere flange; therefore, for the XCell™ ATF 10 System, these two parts
are assembled first. The two Diaphragm Pump hemispheres are assembled with the
diaphragm pointing into the PL pump hemisphere.
e2. Clamp the two hemispheres with the C-clamps, use the three long clamps first, and place
120 degrees to each other about the Diaphragm Pump periphery.
e3. Uniformly and sequentially tighten the clamps, so the diaphragm is compressed evenly
about the periphery of the two pump spheres.
e4. Add the second set of short C-clamps as described above.
e5. Add on the air inlet assembly to the Air inlet nozzle on the PA part.
e6. Carefully invert the assembled pump sphere, so it stands on the long C-clamps.
e7. One may place the pump onto its stand and/or proceed to assemble the entire system.
e8. Torque Settings: ASME clamps: torque to 30 lbft, C-clamp assemblies: torque 20-25lbft
7.6 Assembly
Fully assemble Diaphragm Pump, Filter Housing, reducer and accessories and prepare for Pressure
test. See, Pressure testing and sterilization, (section 8).
7.7 Use
Following successful pressure testing and sterilization reconnect the Filtration Assembly to the
bioreactor (section 9)
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