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10.0 Maintenance
10.1 Diaphragm
It is recommended that a new diaphragm be used with each new run. To avoid premature failure, it
is important to ensure that the diaphragm is seated in the proper orientation.
Use with aqueous liquids only. For use with other fluids contact Repligen for a technical discussion.
When used as instructed in this manual, the diaphragm is designed to last over 500,000 cycles.
10.2 Pump Air Inlet Filter
The replacement of the pump air inlet filter will be determined by how the system is configured. If
the air filter is autoclaved with the Filtration Assembly, it is qualified for 135°C, for 30 minutes, 3
times.
10.3 “O” Rings, gaskets and Quick Connects
The O-rings on the ventilation ports and quick connects (XCell™ ATF 4 System and XCell™
ATF 6 System) should be replaced every two or three runs. Replacement kits are available
from Repligen. HFM Filter “O” rings should be replaced with each new filter. For pump line,
air supply, and vacuum source, all “O” rings and gaskets should be replaced periodically. An
approved lubricant may be used to facilitate coupling of parts containing an “O” ring seal.
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