Introduction
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2 Introduction
Designed for the analysis of chemical processes by NMR, InsightMR is the ideal solution for
both industrial and academic scientists studying or optimizing reactions. InsightMR’s two
components, a flow unit and dedicated software, enable online monitoring of chemical
reactions in real-time under real process conditions.
2.1 Concept
The flow unit enables online monitoring of chemical reaction in real-time under real
conditions. This is achieved by fast and continuous transfer of reactions mixtures from a
reaction vessel into a glass flow tube, located in the NMR probe, with temperature control
from the flow interface to the probe. Designed to work with 5 mm probes, the flow unit is a
versatile proposition to flow chemistry by NMR.
The dedicated InsightMR software is a platform designed for the analysis of chemical
processes by NMR. Integrated acquisition control and data processing features enable on-
the-fly acquisition parameter adjustment based on real-time kinetic data.
2.2 Intended Use
The InsightMR glass flow tube is an insert for standard 5 mm NMR probes. It allows the
transfer of liquid from an external container through a transfer line into the NMR detection
area and back. Once the liquid is in the detection area, NMR data can be acquired either
under static or continuously flowing conditions. A schematic of the intended setup is shown in
the figure Figure 4.2 [}16].
Typically the InsightMR flow unit is used to continuously circulate the liquid from a reaction
vessel through the NMR probe. By this procedure the changing composition of the liquid in
the vessel, i.e. the progress of the reaction, can be continuously monitored. The low volumes
of the system ensure that after a short time the composition in the NMR glass flow tube
corresponds to the composition in the reactor.
The InsightMR modular design allows the user to maintain the system easily. In the case of
contamination from compounds that cannot be removed with simple flushing, the glass flow
tube can be removed and cleaned or replaced. The glass flow tube, and various other
components are highlighted in the figure Figure 4.1 [}15].
The system can be used for other purposes where a flow with changing composition should
be monitored. However the usage as an HPLC-NMR system is not recommended since it is
designed to allow fast transfer with high flow rates, which would cause peak broadening in an
HPLC chromatogram.
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