Chapter 7: Functional description
Fresenius Medical Care multiFiltrate IFU-EN-UK 15A-2015 7-17
7.3.2 Regional anticoagulation with citrate
7.3.2.1 General information on citrate anticoagulation
Regional anticoagulation
with citrate
Citrate can be used for regional anticoagulation and is directly
eliminated from the blood to a large extent by the filter during the CRRT
treatment. The part of the citrate which is inevitably infused into the
body is quickly metabolised by most patients. In the majority of patients,
this prevents a clinically relevant increase of the systemic citrate
concentration.
CVVHD with citrate anticoagulation Min. Max. Resolution Unit
Blood flow 10 200 10 ml/min
Ultrafiltration Off / 10 1800 10 ml/h
UF goal Off / 10 10,000 10 ml
Cont. heparin adm. Off / 0.1 25 0.1 ml/h
Dialysate 600 4800 50 ml/h
Citrate / blood (citrate dose) 2.0 6.0 0.1 mmol/l
Calcium / filtrate (calcium dose) 0 3.0 0.1 mmol/l
Temperature Off / 35 39 0.5 °C
postCVVHDF with citrate anticoagulation Min. Max. Resolution Unit
Blood flow 10 200 10 ml/min
Ultrafiltration Off / 10 1200 10 ml/h
UF goal Off / 10 14,400 50 ml
Cont. heparin adm. Off / 0.1 25 0.1 ml/h
Dialysate 600 4800 50 ml/h
Substituate 600 2400 50 ml/h
Citrate / blood (citrate dose) 2.0 6.0 0.1 mmol/l
Calcium / filtrate (calcium dose) 0.1 3.0 0.1 mmol/l
Temperature Off / 35 39 0.5 °C