16-2 Art: 714378-00F 31-Jan-12
Troubleshooting The i-STAT System is designed to measure fresh whole blood samples. Matrix
effects and interfering substances can be expected when measuring non-whole
blood samples. The following points should be considered when selecting and
testing external quality control samples:
• Aqueoussamplesintendedtoassessbloodgaseswillnotbemeasured
by the i-STAT System unless electrolytes, or at least sodium, are
present.
• Fluorocarbonsamplesarenotcompatible.
• Preserved-cellsamplesarenotcompatible.
• Agedserumandlyophilizedserummaycontaindegradationproducts
or preservatives that interfere with the measurements.
• Matrix effects between aqueous-based and protein-based samples
may cause results from the i-STAT System to differ from reference
methods or other comparative methods.
• Aqueous samples that contain a resistive substance to allow
assessment of conductometric hematocrit measurements will cause
the i-STAT System to extrapolate ambient temperature results to 37 °C
results for pH and PCO
2
as if the sample were whole blood. Since
extrapolation coefficients for aqueous and whole blood samples
differ, results on the i-STAT System for these samples may not agree
with other methods.
While the various cartridges give the same results for whole blood samples, there
may be small differences between generations and types of cartridges for non-
whole blood samples. Generation means major manufacturing changes such as
making the chips smaller. Cartridge types means those that make measurements
at ambient temperature and those that make measurements at 37 °C.
Administrative errors include choosing the wrong method or peer group and
transcription errors.
A level surface includes running the handheld in the downloader/recharger.
7. Review results
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