Rev. Date: 23-May-12 Art: 716969-00J BNP - 5
Non-Heart Failure Population - Females (Age Group)
All
<45
Years
45-54
Years
55-64
Years
65-74
Years
75+
Years
Sample Size (N=)
465 98 75 77 133 82
Median (pg/mL)
26 23 23 37 23 25
Mean (pg/mL)
46 34 34 51 46 69
SD (pg/mL)
70 37 36 48 63 126
95th Percentile
150 89 111 155 159 266
Percentage < 100 pg/mL
88.4% 95.9% 90.7% 89.6% 85.7% 80.5%
Minimum (pg/mL)
0 0 0 0 0 0
Maximum (pg/mL)
837 263 142 230 374 837
* Representative data, results in individual laboratories may vary from these data.
Due to demographic population differences, the reference range should be established at each laboratory.
Heart Failure Population
Plasma samples from 693 patients with diagnosed heart failure (231 females, 462 males) were tested
with the AxSYM BNP assay. All patients in this population were categorized according to the functional
classification system published by the New York Heart Association (NYHA).
22
This system divides heart
failure patients into one of four categories of increasing disease progression (classes I to IV) based upon
a subjective assessment of the patient’s clinical signs and symptoms. The data from this study are
summarized in the following table.*
Heart Failure Population - All
NYHA Functional Class
All I II III IV
Sample Size (N=) 693 124 319 190 60
Median (pg/mL) 298 133 266 335 1531
Mean (pg/mL) 578 320 432 656 1635
SD (pg/mL) 771 388 574 841 1097
5th Percentile 14 9 15 12 188
95th Percentile 2154 1257 1534 2516 >4000
Percentage ≥ 100 pg/mL 74.2% 58.1% 73.0% 79.0% 98.3%
Minimum (pg/mL) 0 3 0 0 14
Maximum (pg/mL) >4000 1651 >4000 >4000 >4000
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