Rev. Date: 23-May-12 Art: 715595-00R cTnI - 7
Interference Testing
The following substances were found to have no significant effect (less than 10%) on the cTnI method,
when added to a plasma pool containing approximately 2 ng/mL of cardiac troponin I, at the concentrations
indicated:
Compound
Test Level
(μmol/L unless otherwise indicated)
Acetaminophen 1660
Allopurinol 294
Ascorbic Acid 227
Acetyl Salicylic Acid 3330
Atenolol 37.6
Caffeine 308
Captopril 23
Chloramphenicol 155
Diclofenac 169
Digoxin 6.15
Dopamine 5.87
Enalaprilat 0.86
Erythromycin 81.6
Furosemide 181
Sodium Heparin* 36 U/mL
Ibuprofen 2425
Isosorbide dinitrate 636
Methyldopa 71
Nicotine 6.2
Nifedipine 1.156
Phenytoin 198
Propanolol 7.71
Salicylic Acid 4340
Theophylline 222
Verapamil 4.4
Warfarin 64.9
*Heparin at 90U/mL was found to decrease the cTnI level by approximately 20%.